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6 Prescription Drugs Medicare Part D Could Stop Covering in 2027 - Check Your Plan Now

Upcoming drug coverage changes could impact your prescriptions.

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Updated June 15, 2026
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Most Medicare beneficiaries assume that if a prescription is covered this year, it will still be covered next year. That isn't always the case. Medicare Part D plans update their formularies annually, and 2027 may bring more changes than usual as insurers continue adjusting to major reforms from the Inflation Reduction Act.

Some retirees may see lower out-of-pocket costs under the redesigned benefit. Others could encounter narrower formularies, higher tiers, or new coverage restrictions for certain medications. For people whose retirement savings are stretched thin, even a small change in prescription coverage can impact their budget. 

Here are some types of drugs that may face greater scrutiny in 2027.

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Specialty medications

Specialty drugs are among the most expensive medications covered by Medicare Part D. They are commonly prescribed for conditions like multiple sclerosis, rheumatoid arthritis, cancer, and other serious illnesses.

Beginning in 2027, insurers will continue operating under the redesigned Part D benefit structure, which requires them to absorb an even larger share of certain high-cost claims. Health policy analysts have suggested that plans may respond by paying closer attention to specialty drug spending. That could result in more prior authorizations required and changes to the formulary.

Brand-name drugs without generic competition

Some medications have no generic equivalent, leaving patients without any alternatives.

These prescriptions often cost substantially more than generic drugs, making them a frequent target for cost-management efforts. In some cases, a drug might remain covered but move to a higher tier. When that happens, beneficiaries must pay higher copays or coinsurance even though the medication remains available.

Biologic medications

Biologic drugs are produced from living organisms and are commonly used to treat autoimmune diseases, certain cancers, and inflammatory conditions.

Because these medications are often expensive, they tend to represent a sizable portion of prescription drug spending. Some experts believe insurers may reevaluate coverage strategies for biologics as they adapt to the redesigned Medicare benefit. Beneficiaries could see changes involving tier placements or cost-sharing structures.

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Drugs that have lower-cost alternatives

Medicare drug plans frequently encourage the use of lower-cost medications when multiple treatment options are available. One tool plans use is step therapy. Under step therapy rules, a patient may be required to try a less expensive drug before coverage is approved for a more costly option.

Policy groups have warned that insurers may expand the use of these programs as they adjust to the financial realities of the redesigned Part D benefits. That does not necessarily mean medications are no longer covered, but access may require additional steps that were not previously required.

Weight-loss medications

Weight-loss drugs remain one of the most closely watched categories in prescription drug coverage.

Medicare has historically restricted coverage for medications prescribed solely for weight loss. Although some newer drugs may qualify for coverage when used to treat other approved conditions, coverage policies continue to evolve.

These medications are also expensive, increasing the likelihood that plans will closely evaluate their fit within future formularies. Beneficiaries using these drugs should review their plan documents carefully during open enrollment.

Medications impacted by Medicare price negotiations

The federal government's Medicare drug price negotiation program is expected to expand over the next few years. While negotiated prices may reduce costs for some beneficiaries, the broader effects on formularies remain unclear. Plans still retain flexibility in how they organize coverage, assign tiers, and manage utilization.

For that reason, beneficiaries taking medication selected for negotiation should avoid assuming coverage will remain unchanged from year to year.

Why some retirees could face narrower formalities in 2027

The redesigned Part D benefit creates different outcomes depending on a beneficiary's prescription needs.

People with extremely high drug costs may benefit from stronger protections against catastrophic spending. Others may not see the same advantages. Some health care analysts have warned that plans could respond by tightening formularies or increasing utilization management efforts, such as prior authorization requirements, to offset higher financial responsibilities.

Beneficiaries who do not receive low-income subsidies and who are not taking drugs subject to negotiated pricing may be more likely to notice these types of changes.

What to do during open enrollment

The Medicare open enrollment period runs from October 15 to December 7 each year. During this window, beneficiaries should compare plans rather than automatically renewing their current coverage. 

A drug that was affordable this year may be placed in a different tier next year. A medication that did not require prior approval may suddenly require additional paperwork.

Before choosing a plan for 2027:

  • Review a plan's updated formulary
  • Search every prescription you take using Medicare's Plan Finder
  • Check for new prior authorization requirements
  • Look for step therapy restrictions
  • Compare total annual drug costs, not just monthly premiums
  • Contact your insurer if a medication appears to have changed status
  • Reach out to your local SHIP counselor for free Medicare guidance

Bottom line

Medicare Part D coverage is never set in stone. Even if your prescriptions are covered today, formulary updates, tier changes, and new utilization rules could impact what you pay in 2027. Taking a few minutes to review your plan during open enrollment may help you avoid unexpected costs and make the right moves before the new coverage year begins.

Medicare plans are required to notify members when covered drugs are being removed or moved to a different tier. Reading these annual notices instead of automatically renewing coverage can help you spot potential problems before you arrive at the pharmacy counter.

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